Indian scientists have reported the design of a new class of synthetic peptides that can not only block the entry of the SARS-CoV-2 virus entry into cells and can also clump the virions (virus particles) together, reducing their ability to infect. The research has been supported under the COVID-19 IRPHA call of SERB Science and Engineering Research Board (SERB), a statutory body of the Department of Science and Technology (DST).
Novel mechanism to inactivate SARS-CoV-2
- IISc Scientists exploited this approach to design peptides that can bind to and block the spike protein on the surface of SARS-CoV-2 virus in collaboration with researchers from the CSIR-Institute of Microbial Technology
- Researchers tested their hypothesis by using a peptide called SIH-5 to target the interaction between the Spike (S) protein of SARS-CoV-2 and ACE2 protein, the SARS-CoV-2 receptor in human cells.
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